Sinusoidal Segment Interactive 3D Visualization
Executable file is available upon request
This movie is an interactive 3D visualization of antipyrine & sucrose compounds percolating through one (#7 out of about 60) Sinusoidal Segment in the In Silico Liver (over 400 time steps). The three grid spaces (pink: sinusoidal, yellow: endothelial, and blue: space of the space of Disse plus hepatocytes) are rendered as concentric cylinders. Two views are provided of these cylinders. One is a side view (upper right) and the other is a head-on view (lower left). At the lower right the raw grid data is directly represented.
For each grid space point there are several options:
Each “smooth” control on the upper left is used to distinguish the spaces; it causes the grid data to be blurred or not. The blurring is being applied as a texture to a cylinder and could be viewed as representing the likelihood that a compound of that type is actually in that location.
The “Show” control selects the space (Sinusoidal, Endothelial and Space of Disse & Hepatocytes (SoD) to be observed (or not).
Selecting “Rotate” causes the cylinder to rotate.
The “>||” and “||<” controls causes in silico time to move one step forward or backward.
To view the movie you need Macromedia Shockwave Player 10 running on a late-model computer (Mac or Win) with openGL and hardware 3D acceleration.
For additional biological and pharmacokinetic detail see:
Hung DY, Chang P, Weiss M, Roberts MS.(2001) Structure-hepatic disposition relationships for cationic drugs in isolated perfused rat livers: transmembrane exchange and cytoplasmic binding process. J Pharmacol Exp Ther. 297:780-9.
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