Recent Publications

Articles in Peer Reviewed Journals (since 2004)

  1. In Silico, Experimental, Mechanistic Model for Extended-Release Felodipine Disposition Exhibiting Complex Absorption and a Highly Variable Food Interaction.  S.H.J. Kim, A.J. Jackson, C.A. Hunt.  PLoS ONE 9(9):e108392 (2014).
  2. Toward modular biological models: defining analog modules based on referent physiological mechanisms.  B.K. Petersen, G.E.P. Ropella, C.A. Hunt.  BMC Systems Biology 8(95) (2014).
  3. Tuneable resolution as a systems biology approach for multi-scale, multi-compartment computational models.  D.E. Kirschner, C.A. Hunt, S. Marino, M. Fallahi-Sichani, J.J. Linderman.  Wiley Interdisciplinary Reviews: Systems Biology and Medicine 6(4):289-309 (2014).
  4. Agent-based modeling: a systematic assessment of use cases and requirements for enhancing pharmaceutical research and development productivity.  C.A. Hunt, R.C. Kennedy, S.H.J. Kim, G.E.P. Ropella.  Wiley Interdisciplinary Reviews: Systems Biology and Medicine 5(4):461-480 (2013).
  5. Falsifying an Enzyme Induction Mechanism within a Validated, Multiscale Liver Model.  G.E.P. Ropella, R.C. Kennedy, C.A. Hunt.  International Journal of Agent Technologies and Systems 4(3):1-14 (2012).
  6. Individualized, discrete event, simulations provide insight into inter- and intra-subject variability of extended-release, drug products.  S.H.J. Kim, A.J. Jackson, R. Hur, C.A. Hunt.  Theor Biol Med Model 9:39 (2012).
  7. Relational Grounding Facilitates Development of Scientifically Useful Multiscale Models.  C.A. Hunt, G.E.P. Ropella, T.N. Lam, A.D. Gewitz.  Theor Biol Med Model 8:35 (2011).
  8. Enabling Clearance Predictions to Emerge from In Silico Actions of Quasi-autonomous Hepatocyte Components.  S. Sheikh-Bahaei, C.A. Hunt.  Drug Metabolism and Disposition 39:1910-1920 (2011). Sheikh-Bahaei_DMD_2011.pdf (author copy)
  9. MDCK Cystogenesis Driven by Cell Stabilization within Computational Analogues.  J.A. Engelberg, A. Datta, K.E. Mostov, C.A. Hunt.  PLoS Comput Biol 7(4): e1002030 (2011).
  10. Moving Beyond In Silico Tools to In Silico Science in Support of Drug Development Research.  C.A. Hunt, G.E.P. Ropella. Drug Development Research 72(2):153-161 (2011). Hunt_DDR_2010.pdf (author copy)
  11. Cloud Computing and Validation of Expandable In Silico Livers.  G.E.P. Ropella, C.A. Hunt.  BMC Systems Biology 4:168 (2010).
  12. Agent-Directed Tracing of Multi-Scale Drug Disposition Events within Normal and Diseased In Silico Livers.  S.H.J. Kim, S. Park, G.E.P. Ropella, C.A. Hunt. International Journal of Agent Technologies and Systems 2(3):1-19 (2010). Kim_IJATS_2010.pdf (author copy)
  13. Computational experiments reveal plausible mechanisms for changing patterns of hepatic zonation of xenobiotic clearance and hepatotoxicity.  S. Sheikh-Bahaei, J.J. Maher, C.A. Hunt.  J Theor Biol 265(4):718-733 (2010). Sheikh-Bahaei_JTB_2010.pdf (author copy)
    * This paper is recommended by Faculty of 1000 Biology *
  14. Tracing Multiscale Mechanisms of Drug Disposition in Normal and Diseased Livers.  S. Park, S.H. Kim, G.E. Ropella, M.S. Roberts, C.A. Hunt.  J Pharmacol Exp Ther 334(1):124-136 (2010).
  15. Identifying the rules of engagement enabling leukocyte rolling, activation, and adhesion.  J. Tang, C.A. Hunt.  PLoS Comput Biol 6(2):e1000681 (2010).
  16. Simulation of lung alveolar epithelial wound healing in vitro.  S.H.J. Kim, M.A. Matthay, K. Mostov, C.A. Hunt.  J R Soc Interface 7:1157-1170 (2010).
  17. Mechanistic insight from in silico pharmacokinetic experiments: roles of P-glycoprotein, Cyp3A4 enzymes, and microenvironments.  T.N. Lam, C.A. Hunt.  J Pharmacol Exp Ther 332(2):398-412 (2010).
  18. A Computational Approach to Resolve Cell Level Contributions to Early Glandular Epithelial Cancer Progression.  S.H.J. Kim, J. Debnath, K. Mostov, S. Park, C.A. Hunt.  BMC Systems Biology 3(1):122 (2009).
  19. At the Biological Modeling and Simulation Frontier.  C.A. Hunt, G.E. Ropella, T.N. Lam, J. Tang, S.H. Kim, J.A. Engelberg, S. Sheikh-Bahaei.  Pharm Res 26(11): 2369-2400 (2009).
  20. Computational Investigation of Epithelial Cell Dynamic Phenotype In Vitro.  S.H.J. Kim, S. Park, K. Mostov, J. Debnath, and C.A. Hunt.  Theoretical Biology and Medical Modelling. 6:8 (2009).
  21. Understanding the Role of Liver Zonation in Toxin Elimination.  S. Sheikh-Bahaei, S.H.J. Kim, S. Sheikhbahaei, and C.A. Hunt.  The International Journal of Intelligent Controls and Systems 14(1): 33-40 (2009).
  22. Multi-Agent Simulation of Self-Organizing Behaviors of Alveolar Cells In Vitro.  S.H.J. Kim, S. Sheikh-Bahaei, and C.A. Hunt.  The International Journal of Intelligent Controls and Systems 14(1): 41-50 (2009).
  23. A Computational Approach to Understand In Vitro Alveolar Morphogenesis.  S.H.J. Kim, W. Yu, K. Mostov, M.A. Matthay, and C.A. Hunt.  PLoS ONE 4(3): e4819 (2009).
  24. Discovering plausible mechanistic details of hepatic drug interactions.  T.N. Lam and C.A. Hunt.  Drug Metab Dispos 37(1):237-246 (2009).
  25. Computational strategies unravel and trace how liver disease changes hepatic drug disposition.  S. Park, G.E. Ropella, S.H. Kim, M.S. Roberts, and C.A. Hunt.  J Pharmacol Exp Therap 328(1):294-305 (2009).
  26. Essential operating principles for tumor spheroid growth.  J.A. Engelberg, G.E. Repolla, C.A. Hunt.  BMC Syst Biol 2:110 (2008).
  27. Evaluating an Hepatic Enzyme Induction Mechanism through Coarse- and Fine-Grained Measurements of an In Silico Liver.  G.E. Ropella, S. Park, and C.A. Hunt.  Complexity. 14(6):28-34 (2008).
  28. Dichotomies Between Computational and Mathematical Models.  C.A. Hunt, G.E. Ropella, S. Park, and J. Engelberg.  Nat Biotechnol 26:737-8 (2008).
  29. In Silico Methods for Unraveling the Mechanistic Complexities of Intestinal Absorption: Metabolism–Efflux Transport Interactions.  Lana X. Garmire and C.A. Hunt.  Drug Metab Dispos 36: 1414-24 (2008).
  30. New Simulation Methods to Facilitate Achieving a Mechanistic Understanding of Basic Pharmacology Principles in the Classroom.  A. Grover, T.N. Lam, and C.A. Hunt.  J Scie Ed Technol 17: 366-72 (2008).    < click here for tutorial >
  31. Predictions of Hepatic Disposition Properties Using a Mechanistically Realistic, Physiologically Based Model.  L. Yan, S. Sheihk-Bahaei, S. Park, G.E. Ropella, and C.A. Hunt.  Drug Metab Dispos 36(4): 759-768 (2008). (Featured Article).
  32. Modeling and Simulation of Hepatic Drug Disposition Using a Physiologically Based, Multi-agent In Silico Liver.  L. Yan, G.E. Ropella, S. Park, M.S. Roberts, and C.A. Hunt.  Pharm Res 25: 1023-36 (2008). Yan_PharmRes25.1023_2008_ac.pdf (author copy)
  33. Synthetic Nano-LDL with Paclitaxel Oleate as a Targeted Drug Delivery Vehicle for Glioblastoma Multiforme.  M. Nikanjam, A.R. Gibbs, C.A. Hunt, T.F. Budinger, and T.M. Forte.  J Cont Release 24: 163-71 (2007).
  34. An In Silico Transwell Device for the Study of Drug Transport and Drug-Drug Interactions.  L.X. Garmire, D.G. Garmire, and C.A. Hunt.  Pharm Res 24: 2171-86 (2007) (Featured Article).
  35. Challenges and rewards on the road to translational systems biology in acute illness: four case reports from interdisciplinary teams.  G. An, C.A. Hunt, G. Clermont, E. Neugebauer, and Y Vodovotz.  J Crit Care 22:169-75 (2007).
  36. Dynamics of in Silico Leukocyte Rolling, Activation, and Adhesion.  J. Tang, K.F. Ley, and C.A. Hunt.  BMC Systems Biology 1: 14 (2007).
  37. Formation of cysts by alveolar type II cells in three-dimensional culture reveals a novel mechanism for epithelial morphogenesis.  W. Yu, X. Fang, A. Ewald, K. Wong, C.A. Hunt, Z. Werb, M.A. Matthay, and K. Mostov.  Mol Biol Cell 18(5): 1693-700 (2007).
  38. Cost-Based Partitioning For Distributed and Parallel Simulation of Decomposable Multiscale Constructive Models.  S. Park, C.A. Hunt, and B.P. Zeigler.  Simulation 82(12): 809-26 (2006).
  39. Physiologically Based Synthetic Models of Hepatic Disposition.  C.A. Hunt, G.E. Ropella, L. Yan, D.Y. Hung, and M.S. Roberts.  J Pharmacokin Pharmacodyn 33(6): 737-72 (2006). Hunt_JPKPD_v33p737_2006.pdf (author copy)
  40. Simulating Properties of In Vitro Epithelial Cell Morphogenesis.  M.R. Grant, K.E. Mostov, T.D. Tlsty, and C.A. Hunt.  PLoS Computational Biology 2(10): e129, 1193-1209 (2006).
  41. An In Silico Analogue of In Vitro Systems Used to Study Epithelial Cell Morphogenesis.  M.R. Grant and C.A. Hunt.  In: C. Priami (Ed.): CMSB 2006, LNCS 4210: 285-97 (2006).
  42. Mechanistic study of the interplay of intestinal transport and metabolism using the synthetic modeling method.  Y. Liu and C. A. Hunt.  Pharm Res 23(3): 493-505 (2006). Liu_PharmRes_v23p493_2006.pdf (author copy)
  43. Studies of Intestinal Drug Transport Using an In Silico Epithelio-Mimetic Device.  Y. Liu and C.A. Hunt.  Biosystems 82(2): 154-167 (2005). Liu_Biosystems_v82p154_2005.pdf (author copy)
  44. Biomimetic in silico devices.  C.A. Hunt, G.E. Ropella, M.S. Roberts, L. Yan.  In: V. Danos and V. Schachter (Eds.): CMBS 2004, LNCS 3082: 35-43 (2005).
  45. Glucose transport to the brain: A systems model.  A.A. Qutub and C.A. Hunt.  Brain Research Rev 49(3): 595-617 (2005).
  46. Plasticity of gene expression in injured human dorsal root ganglia revealed by GeneChip oligonucleotide microarrays.  D. Rabert, Y. Xiao, Y. Yiangou, D. Kreder, L. Sangameswaran, M.R. Segal, C.A. Hunt, R. Birch, P. Anand.   J Clin Neurosci 11(3): 289-99 (2004).
  47. Foundations for Extended Life Cycle Biological Models.  G. Ropella, L. Yan, C.A. Hunt (2003). Internal Technical Report.Ropella_UCITR_2003.pdf

Peer Reviewed Articles in Proceedings (since 2004) and Book Chapters

  1. Future MASON Directions: Community Recommendations. N. Payette, M. Bujorianu, G. Ropella et al. Report of the 2013 MASON NSF Workshop, George Mason University Campus, Fairfax, VA, USA, June 15-16.  GMU-CS-TR-2013-9.pdf
  2. Towards Mechanistically Explanatory Biomimetic Analogs for Fracture Healing. M. Marmor, C. Bahney, and C.A. Hunt. Forthcoming in The Proceedings of the ISCA 27th International Conference on Computers and Their Applications in Industry and Engineering (CAINE-2014), New Orleans, LA, USA, October 13-15.  SEDEManuscript20Jun14.pdf
  3. Mechanistic Agent-based Damage and Repair Models as Hypotheses for Patterns of Necrosis Caused by Drug Induced Liver Injury. A.K. Smith, G.E.P. Ropella, N. Kaplowitz, M. Ookhtens, C.A. Hunt.  In Proceedings of the Summer Simulation Multiconference 2014 (SummerSim '14), The Society for Modeling and Simulation International (SCS), Monterey, CA.  FinalSSCManuscript15May14authCopy.pdf
  4. Zonation of Drug-induced, Hepatic Enzyme Induction: Falsifying Fine Grained Mechanisms within a Validated, Multiscale In Silico Liver. G.E.P. Ropella, C.A. Hunt.  Spring Simulation Multiconference 2012, Agent-Directed Simulation Symposium (ADS'12), The Society for Modeling and Simulation International, Orlando, FL.  Ropella_ADS2012.pdf
  5. Towards Simulation-based Robust Computational Scientific Discovery Systems. L. Yilmaz, T. Oren, C.A. Hunt.  In Proceedings of the Summer Computer Simulation Conference. pp. 75-81, June 26-30, 2011, Hague, Netherlands.  Yilmaz_SCSC2011.pdf
  6. Modeling and Simulation: Synthetic Models and Methods.  C.A. Hunt, A.D. Gewitz, T.N. Lam.  In: Encyclopedia of Systems Biology (W. Dubitzky, O. Wolkenhauer, K.H. Cho, H. Yokota, Eds.), Springer, November 5, 2011 (ID: 00569) Hunt_SyntheticMethods.pdf
  7. Advanced Concepts and Generative Simulation Formalisms for Creative Discovery Systems Engineering.  L. Yilmaz, C.A. Hunt.  In: Intelligent-Based Systems Engineering ISRL 10 (A. Tolk and L.C. Jain, eds.), Ch. 9, pp.233-258 (2011).
  8. Composite Cell Agent Model of Epithelial Culture In Vitro. S.H.J. Kim, C.A. Hunt.  Spring Simulation Multiconference 2011, Agent-Directed Simulation Symposium (ADS'11), The Society for Modeling and Simulation International, Boston, MA.  Kim_ADS2011.pdf
  9. A Robust In Silico Analogue of MDCK Cystogenesis Mimics Growth in Multiple Culture Conditions. J. A. Engelberg, A. Datta, K. E. Mostov, C. A. Hunt.  Spring Simulation Multiconference 2011, Agent-Direction Simulation Symposium (ADS'11), The Society of Modeling and Simulation International, Boston, MA.  Kim_ADS2011.pdf
  10. In Silico Bioreactors for the Computer-Aided Design of Tissue Engineering Applications.  F. Consolo, L. Gaetano, G. Benedetto, C.A. Hunt, U. Morbiducci, F.M. Montevecchi.  In: Computational Engineering: Design, Development and Applications (J.E. Browning and A.K. McMann, eds.), in press (2011).
  11. Predicting Human Hepatic Clearance Using Hypernet Neural Network. S. Sheikh-Bahaei, K.A. Ali, S.R. Bera, C.A. Hunt.  19th International Conference on Software Engineering and Data Engineering (SEDE-2010), San Francisco, CA, June 16-18, 2010, pp. 355-359 (ISBN: 978-1-880843-77-2).  Sheikh-Bahaei_SEDE2010.pdf
  12. Agent-Based Simulation of Drug Disposition in Cirrhotic Liver. S. H. J. Kim, S. Park, G. E. P. Ropella, and C. A. Hunt.  Spring Simulation Multiconference 2010, Agent-Directed Simulation Symposium (ADS'10), The Society for Modeling and Simulation International, San Diego, CA.  Kim_ADS2010.pdf
  13. In Silico White Blood Cell: A Synthetic Model of Leukocyte Rolling, Activation, and Adhesion During Inflammation.  J. Tang and C.A. Hunt.  The Proceedings of the ISCA 22nd International Conference on Computers and Their Applications in Industry and Engineering (CAINE-2009), San Francisco, CA, USA, November 4-6, 2009, 225-230.  Tang_CAINE2009.pdf
  14. Agent-Based Modeling of Alveolar Type II Cyst Formation In Vitro.  S.H.J. Kim, S. Sheikh-Bahaei, and C.A. Hunt.  Spring Simulation Multiconference 2009, Agent-Directed Simulation Symposium (ADS'09), The Society for Modeling and Simulation International, San Diago, CA.  Kim_ADS2009.pdf
  15. Multi-Agent Based Modeling of Liver Detoxification.  S. Sheikh-Bahaei, S.H.J. Kim, and C.A. Hunt.  Spring Simulation Multiconference 2009, Agent-Directed Simulation Symposium (ADS'09), The Society for Modeling and Simulation International, San Diago, CA.  Sheikh-Bahaei_ADS2009.pdf
  16. Generative Parallax Simulation: Toward M&S Formalisms for Creative Problem Solving.  L. Yilmaz, C.A. Hunt.  In: S.J. Mason, R.R. Hill, L. Moench, O. Rose, eds., Proceedings of the 2008 Winter Simulation Conference, Miami, FL, Dec. 7-10, 2008.  Yilmaz_WSC2008.pdf
  17. In Silico Simulation of Epithelial Cell Tubulogenesis.  J.A. Engelberg, M. Kim, K.E. Mostov, and C.A. Hunt, in Proceedings of the 2008 IEEE Annual International Conference of the IEEE Engineering in the Medicine and Biology Society, pp 1036-39, IEEE Press, Piscataway, NJ.   Engelberg_IEEE2008.pdf
  18. Using an In Silico Liver to Evaluate a Hepatic Enzyme Induction Mechanism.  C.A. Hunt and G.E. Ropella, in Proceedings of the 2008 IEEE Annual International Conference of the IEEE Engineering in the Medicine and Biology Society, pp 2415-18, IEEE Press, Piscataway, NJ.  Hunt_IEEE2008.pdf
  19. Mechanistic Simulations Explain Paradoxical Saquinavir Metabolism During In Vitro Vectorial Transport Study.  T.N. Lam TN and C.A. Hunt, in Proceedings of the 2008 IEEE Annual International Conference of the IEEE Engineering in the Medicine and Biology Society, pp 5462-65, IEEE Press, Piscataway, NJ.  Lam_IEEE2008.pdf
  20. In Silico White Blood Cell: Mechanisms Underlying Leukocyte Rolling and Adhesion during Inflammation.  Jon Tang and C. Anthony Hunt.  Spring Simulation Multiconference 2008, Agent-Directed Simulation Symposium (ADS'08), The Society for Modeling and Simulation International, San Diago, CA., pp. 170-76 (ISBN: 1-56555-319-5).  Tang_ADS2008.pdf
  21. Predicting Hepatic Disposition Properties of Cationic Drugs Using a Physiologically Based, Agent-Oriented In Silico Liver.  Li Yan, Sunwoo Park, Shahab Sheikh-Bahaei, Glen E. P. Ropella, and C. Anthony Hunt.  Spring Simulation Multiconference 2008, Agent-Directed Simulation Symposium (ADS'08), The Society for Modeling and Simulation International, San Diago, CA., pp. 162-69 (ISBN: 1-56555-319-5).  Yan_ADS2008.pdf
  22. A Framework and Mechanistically Focused, In Silico Method for Enabling Rational Translational Research.  C. Anthony Hunt, Sergio Baranzini, Michael A. Matthay, and Sunwoo Park.  2008 AMIA Summit on Translational Bioinformatics, San Francisco, CA, March 10-12, 2008. Hunt_AMIA2008.pdf
  23. The multiscale in silico liver.  C. Anthony Hunt, Li Yan, Glen E.P. Ropella, Sunwoo Park, Shahab Sheikh-Bahaei and Michael S. Roberts.  J Crit Care 22: 348-49, Abstracts for the 2007 International Conference on Complexity in Acute Illness (ICCAI), Long Beach, CA, October 5-7, 2007.  Hunt_JCC2007.pdf
  24. Parameter Estimation via Analysis of Fuzzy Clusters (PEAF): An Algorithm to Estimate Parameters of Agent-Based Models.  Shahab Sheikh-Bahaei and C. Anthony Hunt.  In G. Hu, ed., Proc ISCA 20th Intern Conf Comp Appl Ind Engr, ISCA, Cary, NC (ISBN: 978-1-880843-65-9), San Francisco, CA, Novebmer 7-9, 2007. Sheikh-Bahaei_CAINE2007.pdf
  25. Systems Modeling of Alveolar Morphogenesis In Vitro.  Sean H. J. Kim, Sunwoo Park, Wei Yu, Keith E. Mostov, Michael A. Matthay, and C. Anthony Hunt.  op.cit., 141-4.  Kim_CAINE2007.pdf
  26. Tracking Compounds and Their Interactions within In Silico Liver.  Sunwoo Park, Sean H.J. Kim, Glen E.P. Ropella, and C. Anthony Hunt.  op.cit., 257-62.  Park_CAINE2007_01.pdf
  27. Affects of surface detection on shape and growth of model tumor spheroids.  Jesse Engelberg, Glen E. P. Ropella, and C. Anthony Hunt.  op.cit., 53-7.  Engelberg_CAINE2007.pdf
  28. Simulation Processors and Their Collaboration for DEVS Models Integrated with Universal Coupling Specification.  Sunwoo Park, Sean H.J. Kim, and C. Anthony Hunt.  op.cit., 151-5.  Park_CAINE2007.pdf
  29. DEVS Peer-to-Peer Protocol for Distributed and Parallel Simulation of Hierarchical and Decomposable DEVS Models.  Sunwoo Park, Sean H.J. Kim, C. Anthony Hunt, and Dongsun Park.  In Press: Proceedings of the International Symposium on Information Technology Convergence (ISITC), Jeonju, Korea, November 23-24, 2007.  Park_ISITC2007.pdf
  30. Prediction of In Vitro Hepatic Biliary Excretion Using Stochastic Agent-Based Modeling and Fuzzy Clustering.  Shahab Sheikh-Bahaei and C. Anthony Hunt.  In: L. F. Perrone, et al., eds., Proceedings of the 37th conference on Winter Simulation, Monterey, CA, Dec 03 - 06, 1617-24, 2006.  Sheikh-Bahaei_WSC2006.pdf
  31. Understanding Emergent Biological Behaviors: Agent Based Simulations of In vitro Epithelial Morphogenesis in Multiple Environments.  Mark R. Grant, Sean H. J. Kim, and C. Anthony Hunt.  In: Proceedings of the Sixth International Conference on Complex Systems, June 25-30, Boston, MA, Ed: A. Minai, D. Braha, Y. Bar-Yam, #42 (2006).  Grant_ICCS2006.pdf
  32. Simulating In Vitro Epithelial Morphogenesis in Multiple Environments.  Mark R. Grant, Sean H. J. Kim, and C. Anthony Hunt.  In: Proc 5th Comp Syst Bioinform Conf (CSB 2006), IEEE Computer Society Press, 381-4 (2006).  Grant_CSB2006.pdf
  33. Coupling Permutation and Model Migration Based on Dynamic and Adaptive Coupling Mechanisms.  Sunwoo Park and C. Anthony Hunt.  In: Proc 2006 DEVS Symp, Sp Simul Conf, (Huntsville, AL, Apr 2-6), SCS Press, San Diego, CA, 9-15 (2006).  Park_SprSim2006.pdf
  34. In Silico Hepatocyte: Agent-based Modeling of the Biliary Excretion of Drugs In Vitro.  Shahab Sheikh-Bahaei, Glen E. P. Ropella, and C. Anthony Hunt.  In: L. Yilmaz, et al., eds., Proc 2006 Agent-Direc Simul Symp (Huntsville, AL, Apr 3-9), SCS Press, San Diego, CA (ADS'06), 157-163 (2006).  Sheikh-Bahaei_SprSim2006.pdf
  35. Agent-Based Simulations of In Vitro Multicellular Tumor Spheroid Growth.  Engelberg, Jesse A., Ganguli, Suman, and C. Anthony Hunt.  op.cit., 141-148.  Engelberg_SprSim2006.pdf
  36. Similarity measures and validation in automated modeling.  D. A. Nag, Glen E. P. Ropella, and C. A. Hunt.  Proceedings: Huntsville Simulation Conference, Huntsville, AL, October 25-27, 2005.  Nag_HSC2005.pdf
  37. Modeling and Simulation of Hepatic Drug Metabolism: In Silico Hepatic Intrinsic Clearance.  Shahab Sheikh-Bahaei, Glen E. P. Ropella, C. Anthony Hunt, in Systems Engineering and Autonomous Control: A Tribute to Professor Mo Jamshidi, ed. Aly El-Osery and Edward Tunstel, TSI, Inc. San Antonio (ISBN: 1-889335-28-2) pp. 137-146 (2006).  Sheikh-Bahaei_SEAC2006.pdf
  38. Methodological Considerations of Heuristic Modeling of Biological Systems.  Glen E. P. Ropella, C. Anthony Hunt, and Shahab Sheikh-Bahaei.  In: Proc 9th World Multi-Conf Systemics, Cybernetics and Informatics, Orlando, FL July 10-13, 2005.  Ropella_WMSCI2005.pdf
  39. Using Heuristic Models to Bridge the Gap Between Analytic and Experimental Models in Biology.  Glen E. Ropella, C. Anthony Hunt, Dev A. Nag.  In: L. Yilmaz, ed., Proc 2005 Agent-Direc Simul Symp (San Diego, CA, Apr 2-8), Simulation Series 37(2), SCS Press, San Diego, CA (ADS'05), 182-190.  Ropella_ADS2005.pdf
  40. In Silico Modeling of Blood-Brain Barrier: An Agent-Based Simulation of Cerebral Glucose Transport.  Sean H.J. Kim, Amina Qutub, C. Anthony Hunt.  ADS'05, op.cit. 177-81.  Kim_ADS2005.pdf
  41. Agent-Based Simulation of In Vitro Hepatic Drug Metabolism: In Silico Hepatic Intrinsic Clearance.  Shahab Sheikh-Bahaei, Glen E. P. Ropella, and C. Anthony Hunt.  ADS'05, op.cit. 157-163.  Sheikh-Bahaei_ADS2005.pdf
  42. Generic Model Partitioning with LookAhead k: A Multi-Scale Partitioning Algorithm for DEVS Biomimetic In Silico Devices.  Sunwoo Park, C. Anthony Hunt, and Bernard P. Zeigler.  ADS'05, op.cit.  Park_ADS2005_01.pdf
  43. PISL: A Large-Scale In Silico Experimental Framework for Agent-Directed Physiological Models.  Sunwoo Park, C. Anthony Hunt, and Glen E. P. Ropella.  ADS'05, op.cit. 205-210.  Park_ADS2005_02.pdf
  44. Modeling Mammary Gland Morphogenesis as a Reaction-Diffusion Process.  M.R. Grant, C.A. Hunt, L. Xia, J.E. Fata, M.J. Bissell.  In: Proceedings of the 26th Annual International Conference of the IEEE EMBS, San Francisco, CA, USA, Sept. 1-5, 2004, 679-682.  Grant_IEEE2004.pdf
  45. An Agent-based Computational Approach for Representing Aspects of In Vitro Multi-cellular Tumor Spheroid Growth.  S. Chen, S. Ganguli, C.A. Hunt.  IEEE'04, op.cit. 691-694.  Chen_IEEE2004.pdf
  46. Representing Intestinal Drug Transport In Silico: An Agent-Oriented Approach.  Y. Liu, C.A. Hunt.  IEEE'04, op.cit. 770-773.  Liu_IEEE2004.pdf
  47. Modeling Transport Kinetics with StarLogo.  D.Y. Wong, A. Qutub, C.A. Hunt.  IEEE'04, op.cit. 845-848.  Wong_IEEE2004.pdf
  48. A Novel Stepwise Normalization Method for Two-Channel cDNA Microarrays.  Y. Xiao, C.A. Hunt, M.R. Segal, Y.H. Yang.  IEEE'04, op.cit. 2921-2924.  Xiao_IEEE2004.pdf
  49. Modeling Liver Physiology: Combining Fractals, Imaging and Animation.  D.W. Lin, S. Johnson, C.A. Hunt.  IEEE'04, op.cit. 3120-3123.  Lin_IEEE2004.pdf
  50. Applying Models of Targeted Drug Discovery to Gene Delivery.  T.N. Lam, C.A. Hunt.  IEEE'04, op.cit. 3535-3538.  Lam_IEEE2004.pdf
  51. Simulating Leukocyte-Venule Interactions - A Novel Agent-Oriented Approach.  J. Tang, C.A. Hunt, J. Mellein, K. Ley.  IEEE'04, op.cit. 4978-4981.  Tang_IEEE2004.pdf
  52. The Necessity of a Theory of Biology for Tissue Engineering: Metabolism-Repair Systems.  S. Ganguli, C.A. Hunt.  IEEE'04, op.cit. 5031-5034.  Ganguli_IEEE2004.pdf
 
 

The premise of the agent paradigm, its related theory and methodologies together with advances in multilevel modeling of complex systems of interactions opened new frontiers for advancing the physical, natural, social, military, and information sciences and engineering...